hexose monophosphate shunt

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Fig. 1.
Schematic representations of the oxidative part of the hexose–monophosphate shunt and relevant sources of oxidative load (A) and the simplified reaction network that captures the essential features of these pathways (B) (see Supporting Text section 1 for details) and that is used in our analysis. Cat, catalase; G6P, glucose 6-phosphate; GL6P, gluconolactone 6-phosphate; Glc, glucose; GO6P, gluconate 6-phosphate; G6PD, glucose-6-phosphate dehydrogenase; GO6PD, gluconate-6-phosphate dehydrogenase; GRX, glutaredoxin; GSH, reduced glutathione; GSSG, oxidized glutathione; GPx, glutathione peroxidase; GSR, glutathione reductase; HbSH, hemoglobin; HbSSG, glutathionyl-hemoglobin; HK, hexokinase; SOD, superoxide dismutase.